- 2009: Portrayed famed chef Julia Child in Nora Ephron's "Julie & Julia"
- 2008: Starred in the film version of the ABBA musical "Mamma Mia!"; earned a Golden Globe nomination for Best Actress in a Musical and a Grammy nomination for the soundtrack
- 2008: Portrayed Sister Aloysius Beauvier in the film adaptation of John Patrick Shanley's play "Doubt"; earned Golden Globe and Academy Award nominations for Best Actress
- 2007: Cast in Michael Cunningham's film adaptation of Susan Minot's novel "Evening"; also starring her daughter, Mamie Gummer as a younger version of herself
- 2007: Portrayed a TV journalist in the Robert Redford directed drama, "Lions for Lambs"
- 2006: Cast in Robert Altman's adaptation of Garrison Keillor's "A Prairie Home Companion"
- 2006: Cast as the all-powerful magazine editor in the fashionista comedy "The Devil Wears Prada," based on Lauren Weisberger's best-selling novel; earned SAG and Oscar nominations for Best Actress
- 2005: Played a psychoanalyst who discovers that her client (Uma Thurman) is dating her son in "Prime"
- 2004: Cast as Aunt Josephine opposite Jim Carrey in "Lemony Snicket's A Series of Unfortunate Events" based on the books by Daniel Handler
- 2004: Featured with Denzel Washington in "The Manchurian Candidate" directed by Jonathan Demme; received a Golden Globe nomination for Best Supporting Actress
- 2003: Portrayed Hannah Pitt in the HBO miniseries adaptation of Tony Kushner's "Angels in America"; fourth collaboration with Mike Nichols
- 2002: Starred as author Susan Orlean in the film "Adaptation"; loosely based on Orlean's book The Orchard Thief; received an Academy Award nomination for a supporting role
- 2002: Cast as Clarissa Vaughn in the film adaptation of the Pulitzer-winning novel "The Hours"; received a Golden Globe nomination
- 2001: Returned to the stage to star in the New York Shakespeare Festival production of "The Seagull"; staged by Mike Nichols
- 1999: Portrayed NYC violin teacher Roberta Guaspari-Tzavaras in "Music of the Heart"; was required her to learn to play the violin; received Academy Award, Golden Globe and SAG nominations
- 1998: Featured in the ensemble drama "Dancing at Lughnasa"; adapted from Brian Friel's award-winning play
- 1998: Received star on the Hollywood Walk of Fame (September 16)
- 1998: Earned eleveth Academy Award nomination for her role in "One True Thing"
- 1997: Debut as executive producer (also starred) with her first TV-movie in eighteen years, "...First Do No Harm"
- 1996: Co-starred with Diane Keaton and Leonardo DiCaprio in "Marvin's Room"
- 1995: Received tenth Academy Award nomination as an Italian-born Midwestern woman who has a brief affair with a photographer (Clint Eastwood) in "The Bridges of Madison County"; also directed by Eastwood
- 1994: First role as an action heroine, "The River Wild"
- 1992: Cast as an aging actress who trades her soul for a youthful appearance in the black comedy "Death Becomes Her"
- 1990: Co-starred with Shirley MacLaine in "Postcards from the Edge" a screen adaptation of Carrie Fisher's semi-autobiographical novel; third collaboration with Mike Nichols
- 1989: First comedic role in "She-Devil" starring opposite Roseanne
- 1988: Portrayed Lindy Chamberlain, a religious Australian woman accused of murdering her own child in "A Cry in the Dark (Evil Angels)"; received an Academy Award nomination for Best Actress
- 1987: Re-teamed with Jack Nicholson for "Ironweed"
- 1986: Cast opposite Jack Nicholson in "Heartburn"; second collaboration with Nichols
- 1985: Played author Isak Dinesen in Sydney Pollack's lavish biopic "Out of Africa"
- 1983: Recieved strong reivews and an Oscar nomination for "Silkwood"; first film with Mike Nichols
- 1982: Earned second Academy Award for her portrayal of a Polish concentration camp survivor in "Sophie's Choice"
- 1981: First starring role, "The French Lieutenant's Woman"
- 1979: Cast in the Woody Allen film, "Manhattan" as Allen's ex-wife and as a politician's mistress in "The Seduction of Joe Tynan"
- 1979: Won first Academy Award for her portrayal of a dissatisfied wife and mother in "Kramer vs. Kramer"
- 1978: Earned first Oscar nomination for her supporting role in "The Deer Hunter"
- 1978: Won an Emmy for her starring role as a Catholic married to a Jewish man in the NBC miniseries "Holocaust"
- 1977: TV-movie debut as the wife of a professional hockey player accused of manslaughter in "The Deadliest Season" (CBS)
- 1977: Made film debut in "Julia" opposite Jane Fonda and Vanessa Redgrave
- 1977: TV acting debut, reprising her stage role in the PBS "Theater in America" production of "Secret Service"
- 1976: Appeared in the Central Park productions of "Henry V" and "Measure for Measure"
- 1976: Appeared in the double bill "27 Wagons Full of Cotton" and "A Memory of Two Mondays"; received a Tony nomination as Featured Actress in a Play for the former
- 1975: Broadway debut, "Trelawny of the Wells" at Lincoln Center's Vivian Beaumont Theater
- 1971: Professional acting debut in NYC in "The Playboy of Seville" at the Cubiculo Theatre
- 1961: Studied to become an opera singer at age 12
- Appeared with the Yale student repertory company in the Stephen Sondheim-Burt Shevelove musical, "The Frogs"
- Acted with Green Mountain Guild, a traveling theater company in Vermont
- Raised in New Jersey



