- 2009: Played an evil Pharaoh in "Night at the Museum: Battle of the Smithsonian"; also voiced the Lincoln Memorial Statue and The Thinker
- 2008: Appeared in David Schwimmer's directorial debut, "Run, Fat Boy, Run"
- 2007: Starred in Aaron Sorkin's Broadway play, "The Farnsworth Invention" as RCA head David Sarnoff
- 2007: Reprised roles for "The Simpsons Movie" an animated feature based on the long running Fox series
- 2005: Cast as Sir Lancelot and other roles in "Spamalot," Eric Idle's Broadway musical version of ''Monty Python and the Holy Grail; earned a Tony nomination for his role
- 2004: Had a memorable role in the Ben Stiller comedy, "Along Came Polly"
- 2004: Starred in the black comedy "Eulogy" which follows three generations of a family, who come together for the funeral of the patriarch
- 2004: Featured in the comedy "Dodgeball: A True Underdog Story" starring Ben Stiller and Vince Vaughn
- 2004: Portrayed psychiatrist Craig "Huff" Huffstodt in the Showtime drama "Huff"; also produced; earned Emmy and SAG nomination in 2005 for Best Male Lead
- 2002: Starred in the NBC midseason sitcom "Imagine That"; portrayed multiple characters; series canceled after two airings
- 2001: Played a Spanish actor in love with a popular movie star in "America's Sweethearts"
- 2001: Co-starred in the fact-based NBC miniseries "Uprising" about the Warsaw Ghetto resistance movement during WWII
- 2000: Cast in the Stephen Frears directed televised play, "Fail Safe"; broadcast live in black and white on CBS
- 2000: Reteamed with Don Bluth and Gary Goldman, contributing vocal skills to the animated feature "Titan A.E."
- 1999: Starred as composer Marc Blitzstein in Tim Robbins' "Cradle Will Rock"
- 1999: Acted opposite Jack Lemmon in the ABC movie, "Tuesdays with Morrie"; earned a SAG nomination in same category as Lemmon who won the award for Best Actor
- 1998: Portrayed Animal, a gonzo New York cameraman who helps Matthew Broderick's scientist slow down "Godzilla"
- 1998: Cast as Walter Plane, the wealthy boyfriend of Gwyneth Paltrow's Estella in the contemporary remake of "Great Expectations"
- 1998: Had a small role in Woody Allen's "Celebrity"
- 1997: Voiced Bartok in the animated feature "Anastasia"; first association with animators Don Bluth and Gary Goldman; would reprise his role in the 1999 straight-to video prequel "Bartok the Magnificent"
- 1996: Delivered a tour-de-force, scene-stealing performance as the gay Guatemalan houseboy in "The Birdcage"
- 1996: Joined cast of "Mad About You" (NBC) in recurring role of a dog walker
- 1994: Portrayed weaselly network executive Albert Freedman in Robert Redford's "Quiz Show"
- 1994: Had a recurring role as David, one of Phoebe Buffay's boyfriends in "Friends" (NBC); earned an Emmy nomination in 2003
- 1991: Played the best friend of the title character on the FOX sitcom "Herman's Head"
- 1990: Feature film debut, "Cool Blue" (filmed in 1988) opposite Woody Harrelson; released direct to video
- 1990: First released film, the box-office hit "Pretty Woman"; played a detective
- 1989: Voiced several characters, including Moe the bartender and Apu the Kwik-E-Mart owner, on the FOX animated sitcom, "The Simpsons"; earned an Emmy nomination for Outstanding Voice-Over Performance in 2009
- 1988: Early TV appearance in an episode of the NBC sitcom "Family Ties"
- 1988: TV-movie debut, "Frank Nitti: The Enforcer" (ABC)
- 1987: Relocated to Los Angeles to pursue career in TV
- 1986: First TV appearance, the short-lived ABC series "Joe Bash"; earned him SAG card; part was edited out
- 1985: Professional stage debut in Harold Pinter's "The Dumb Waiter" in Boston
- Moved to New York to pursue stage career; bartended at the restaurant Arcadia
- Worked as a stand-up comedian, including a six-month stint at the Comedy Store
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